Cyclin D1 Levels are Involved in the Resistance to m-TOR Inhibitors in Human Bronchial Carcinoids Abstract #962

Introduction: Bronchial carcinoids (BC) are still orphans of medical therapy. We previously demonstrated that the typical BC human cell line NCI-H727 is sensitive to Everolimus, in terms of cell viability reduction, while the atypical human BC cell line NCI-H720 is not. However, the mechanisms underlying this phenomenon have not been fully clarified.
Aim(s): To investigate the mechanisms of resistance to mTOR inhibitors in BC cells.
Materials and methods: Cell cycle protein profiling was performed throughout G0/G1/S phases evaluating important complexes regulated during these transition phases at different cell-cycle times, such as CDK2/Cyclin E, CDK4/CyclinD1 and p27Kip1.
Conference: 11th Annual ENETS Conference (2014)
Category: Basic Science - mTOR and other pathways, signalling, receptors
Presenting Author: Master degree Katiuscia Benfini
Keywords: BC, mTOR

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