Multi-parametric risk assessment of patients with Carcinoid Heart Disease - A project of the ENETS CHD Task Force

Level: Level 3

Launch date: Q4 2023

Task force chairs: Simona GLASBERG & Joseph DAVAR

Principle investigators: Joseph DAVAR & Sanjeev BHATTACHARYYA

Project description:

This study is organized by the ENETS CHD Task Force and aims to develop a risk-of-death score combining clinical, echocardiographic, and biochemical markers to risk stratify patients with carcinoid heart disease to help determine appropriate therapy.

All data will be retrospectively collected from ENETS multidisciplinary centers and centers specialized in the field, to guarantee quality data.

The primary outcome measure will be overall survival (regardless of cause of death).

T0 will be defined as the date from diagnosis of severe carcinoid heart disease. Survival will be defined as date of diagnosis of carcinoid heart disease to date of death (or last follow-up if patient alive at time of data cut-off).

The secondary outcome measures will include:

• Need of cardiac surgery and time to cardiac surgery (defined as date of diagnosis of severe carcinoid heart disease to date of cardiac surgery).
• Cardiovascular Death. Defined as death due to carcinoid heart disease or related heart failure according to the local site investigator.