Decreased Serum Amyloid A1 as Potential Diagnostic Marker for Gastro-Entero-Pancreatic Neuroendocrine Neoplasms

#2173

Introduction: Gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) are rare tumors with an increased incidence reported in recent years. Researchers have shown that tumor cells produce and secrete more exosomes compared with normal cells. Serum amyloid A1 (SAA1) is elevated in patients with liver cancer, lung cancer, breast cancer, prostate cancer and endometrial cancer. However, the relation between SAA1 and GEP-NENs remains unclear.

Aim(s): To explore circulating exosomes biomarkers which may do favor for diagnosis and treatment to GEP-NENs, and evaluate their biological behavior accurately.

Materials and methods: Using iTraq analysis to identify 96 differentiated proteins from the circulating exosomes of the GEP-NENs patients and healthy subjects.To compare positive incidence of SAA1 in cancer tissues and peri-cancer tissues of 43 GEP-NENs patients by immunochemistry analysis.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Qiyun T

Authors: Na H, Qiyun T,

Keywords: Exosomes, Serum amyloid A1, Circulating biomarkers, Diagnosis,

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