Determination of a Prognostic Classification System in Metastatic Grade 1 and 2 Pancreatic Neuroendocrine Tumors (PNETs)

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Introduction: There is no clinical prognostic risk stratification tool available for metastatic grade 1 and 2 PNETs, which are a heterogeneous group.

Aim(s): This is of particular importance as there are a number of systemic therapies available for these patients.

Materials and methods: A retrospective case analysis was performed on 139 cases from seven NET centres based throughout Europe and South America. Eleven clinical and six laboratory data were collected and multivariate regression analysis was performed to identify a panel of prognostic markers. Inclusion criteria were grade 1 and 2 (based on Ki-67) pancreatic NETs, metastatic disease, and diagnosis at least five years ago. Familial syndromes were excluded.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Fernández Plana J, Bestanti C, Thirlwell C, Campana D, Handkiewicz Junak D,

Keywords: classification system, PNETS, neuroendocrine tumors ,