Differential Claudin-1 Gene Expression in Neural Crest-Derived Tumors of Common Embryological Origin

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Introduction: Pheochromocytoma and paraganglioma are neural crest-derived tumors originating from chromaffin cells, with the former being intra–adrenal in location, while the latter are extra-adrenal.

Aim(s): To investigate the expression of claudin-1(CLDN1), a tight junction protein marker for metastasis and tumor progression, in neural crest-derived tumors.

Materials and methods: Study comprised of 44 pheochromocytoma, 22 paraganglioma and 11 normal adrenal tissue served as control. RNA extracted from each FFPE tissue was reverse transcribed. Real time PCR experiments were performed to study the gene expression on each sample with GAPDH as control.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Philip B, Smith R, Lam A,

Keywords: Claudin-1,