Differential Protein Expression in Small Intestinal Carcinoids and Liver Metastases

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Introduction: Small intestinal carcinoids (SICs) are being increasingly detected, yet often with metastatic disease. Little is known about the molecular pathways important in the development of metastasis.

Aim(s): To use a novel Protein Pathway Array (PPA) to identify key pathways in the mechanism of SIC metastasis development.

Materials and methods: SICs, normal small bowel, liver mets and normal liver were harvested from the same patients. Extracted proteins were separated, and Western blots performed. Significant Analysis of Microarray was used to select differentially expressed proteins. Tissue microarray (TMA) was constructed from archived specimens and stained by immunohistochemistry.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Kim M, Wang D, Cui M, Ward S, Ye F,

Keywords: neuroendocrine, tumor, proteomics,