Differential Somatostatin and CXCR4 Chemokine Receptor Expression in Primary Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NEN) and Their Metastases Abstract #1302

Introduction: Somatostatin receptors (SSTR) are known for their overexpression in well-differentiated GEP-NEN, where they serve as molecular targets for different imaging and treatment modalities. The chemokine receptor CXCR4, in contrast, is present mainly in highly proliferative and advanced tumors.
Aim(s): Evaluation of the SSTR, CXCR4 and Ki-67 expression in primary tumors (PT) (n=50) and metastases (MTS) (n=76) of GEP-NEN from 3 different places of origin (small intestine, pancreas, colon/rectum).
Materials and methods: The SSTR and CXCR4 expression was determined by means of immunohistochemistry and rated by means of the Immunoreactive Score (0-12 points).
Conference: 13th Annual ENETS conference (2016)
Category: Basic Science - mTOR and other pathways, signalling, receptors
Presenting Author: Dr. Daniel Kaemmerer

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