Differential Somatostatin and CXCR4 Chemokine Receptor Expression in Primary Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NEN) and Their Metastases

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Introduction: Somatostatin receptors (SSTR) are known for their overexpression in well-differentiated GEP-NEN, where they serve as molecular targets for different imaging and treatment modalities. The chemokine receptor CXCR4, in contrast, is present mainly in highly proliferative and advanced tumors.

Aim(s): Evaluation of the SSTR, CXCR4 and Ki-67 expression in primary tumors (PT) (n=50) and metastases (MTS) (n=76) of GEP-NEN from 3 different places of origin (small intestine, pancreas, colon/rectum).

Materials and methods: The SSTR and CXCR4 expression was determined by means of immunohistochemistry and rated by means of the Immunoreactive Score (0-12 points).

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Kaemmerer D, Träger T, Sänger J, Schulz S, Lupp A,

Keywords: somatostatin receptor, chemokine receptor, sstr,

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