Difficulties in Diagnosis and Management of Neuroendocrine Tumors of the Head and Neck: A Case Report

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Introduction: Primary neuroendocrine carcinomas (NEC) are uncommon head and neck malignancies. They present with a varied histopathologic spectrum in sinonasal and other subsites.

Aim(s): To present a case report of the difficulty of neuroendocrine carcinoma diagnosis of ethmoidal labyrinth sphenoid bone.

Materials and methods: A 28-year-old female patient presented with submandibular adenopathy of the right side on May 2009. She underwent a radical neck dissection in August 2009. Metastases of high grade NEC were reported by a pathologist. She received six cycles of adjuvant CT with etoposide (100mg/m2 days 1-3) and cisplatin (75 mg/m2 day 1) between September 2009 and March 2010. Relapse-free period was 16 months. Neck lymph node metastases of the left side and primary tumor of ethmoidal labyrinth were detected by PET/CT in August 2011. Lateral rinotomy, removal of the tumor and selective neck dissection of the left side was performed in August 2011. Radiotherapy to the ethmoidal labyrinth and to the neck was performed after surgery. CT with etoposide and cisplatin was started in September 2011. Up to now, the patient has received three of a planned six cycles

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Markovich A, Orlova K, Orel N, Kuzminov A, Gorbunova V,

Keywords: NEC, CT scan, rhinolaryngoscopy,