Diffuse Expression of Osteopontin, Endostatin and Angiopoietin 1 in Neuroendocrine Neoplasm Tissues

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Introduction: Recent data show a characteristic pattern of selected angiogenic factors of plasma levels: endostatin(END), osteopontin(OPN), angiopoietin 1 & 2 (Ang-1&2) in patients with neuroendocrine neoplasm (NEN) in comparison to healthy controls.

Aim(s): 1.To analyze expression of these peptides in NEN tissues using immunohistochemistry (IHC) with monoclonal antibody for: END, OPN, Ang-1 & 2. 2.To compare their IHC expression in NEN tissues with their plasma levels from the same patient.

Materials and methods: The IHC staining was performed on tissue sections from paraffin-embedded blocks obtained after surgery or core needle biopsy from nine patients with a histopathological diagnosis of NEN.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Mełen-Mucha G, Musial J, Kordek R, Stepien H,

Keywords: NEN, angiogenic factors, IHC,