Distinct Cut-Off Values of Ki-67-index for NET-Grading in a Large German Multicentrer Cohort Abstract #213

Introduction: Grading (G) of neuroendocrine tumors (NET) according to ENETS is based on immunhistochemical staining of Ki-67 antigen. Close margins between G1 and G2 NET often fail to differ in survival analysis.
Aim(s): Analysis of Ki-67 values using different cut-off values and correlation with overall survival in a large multicenter cohort of the German NET Registry.
Materials and methods: The German NET Registry (G-NET-Reg) collects data from histologically proven NET diagnoses since 1999 from 28 centers in Germany. Ki-67 values, histopathological classification, clinical data as well as information on overall and NET-specific outcome were obtained and statistically analyzed with regard to prognosis.
Conference: 8th Annual ENETS Conference (2011)
Category: Clinical
Presenting Author: Ulrich-Frank Pape

To read results and conclusion, please login ...

Further abstracts you may be interested in

#134 Gastrointestinal neuroendocrine tumors: tumor characteristics and long-term clinical outcome in the German NET registry
Introduction: Prognosis of neuroendocrine tumors (NETs) has been difficult to predict due to heterogenous tumor biology, various classification systems, and lack of reliable and recent data due to the rarity of these tumors.
Conference: 7th Annual ENETS Conference (2010)
Category: Clinical
Presenting Author: Dr. Ulrich-Frank Pape
Authors: Maasberg S, König A, Rinke A, Anlauf M, ...
#136 Prevalence, severity and clinical outcome of malnutrition in gastroenteropancreatic neuroendocrine tumors
Introduction: Malnutrition is well-known to unfavorably influence clinical prognosis in patients (pts) with malignant diseases. However, in patients with neuroendocrine tumors (NET) prevalence and outcome of malnutrition are unknown although the gastroenteropancreatic system is most frequently involved.
Conference: 7th Annual ENETS Conference (2010)
Category: Clinical
Presenting Author: Mr Sebastian Maasberg
#363 Clinicopathological characteristics are capable of predicting long-term outcome of gastrointestinal neuroendocrine tumours in Germany
Introduction: Neuroendocrine tumours (NET) are a rare and heterogeneous group of neoplasm. Throughout the last decades the classification of NET has been both difficult and incoherent. Therefore making prognostic straticifation often difficult.
Conference:
Category: Basic
Presenting Author: Sebastian Maasberg
Keywords: outcome
#561 Determinants of Long-Term Outcome for Rectal NETs from a Large German Multicentre Cohort
Introduction: Neuroendocrine tumors (NET) of the rectum are a rare subgroup of NETs with mostly favorable prognosis. Some, however, tend to have a poorer outcome.
Conference: 9th Annual ENETS Conference (2012)
Category: Clinical
Presenting Author: Sebastian Maasberg
#742 Evaluation of Relevant Factors of Prognosis Among a Large German Multi-Centric Cohort–Results from the German NET Registry
Introduction: Neuroendocrine neoplasms (NEN) are a rare tumor entity with varying biological behavior.
Conference: 10th Annual ENETS Conference (2013)
Category: Epidemiology/Natural history/Prognosis - Prognosis
Presenting Author: Sebastian Maasberg