Does Biopsy Reliably Identify Grade In Gastroenteropancreatic Neuroendocrine Tumors? Abstract #837

Introduction: A new proliferation-based grading system has proved important in establishing prognosis and guiding therapy in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Biopsies are often performed for grading but little is known about their reliability in assigning grade.
Aim(s): To determine the accuracy of grade identification in virtual biopsies (VBs) of GEP-NETs.
Materials and methods: Twenty cases of resected G1 (11) or G2 (9) GEP-NETs were selected and grade assigned on the whole section (WS) by mitotic index and Ki-67-index. VBs (total 411) were constructed by leaving different, randomly selected and progressively smaller (30 - 0.25 mm sqd) areas of the WS unmasked. Number of neoplastic cells, Ki-67 index and grade were quantified in each VB and compared with Ki-67 and grade assessed on the WS.
Conference: 11th Annual ENETS Conference (2014)
Category: Pathology, grading, staging
Presenting Author: Prof Federica Grillo

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