Dosimetry with 111In-octreotide and Coinfusion of Amino Acids in the Prediction of Nephrotoxicity in Neuroendocrine Tumors after PRRT with 90Y-DOTATOC

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Introduction: Kidneys are the critical organs in PRRT. A dosimetry protocol was implemented in an ongoing study to estimate the biological effective dose (BED) on the kidneys after 90Y-DOTATOC therapy.

Aim(s): 111In-octreotide dosimetry with amino acid infusion is feasible and can be used in the prediction of post-PRRT evolution of the renal function.

Materials and methods: Whole body images were acquired at four time points after an 111In-octreotide injection with 2L amino acid coinfusion, assuming similar kinetics of 111In-octreotide and 90Y-DOTATOC. Regions of interest were drawn, blood and urine were collected, kidney volumes were measured, and all put into OLINDA software, which led to organ BED after four cycles 90Y-DOTATOC.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Van Binnebeek S, Baete K, Vanbilloen B, Terwinghe C, Mottaghy F,

Keywords: PRRT, 90y-DOTATOC, dosimetry, 111in-octreotide, amino acids,