Dosimetry with 111In-octreotide and Coinfusion of Amino Acids in the Prediction of Nephrotoxicity in Neuroendocrine Tumors after PRRT with 90Y-DOTATOC Abstract #335

Introduction: Kidneys are the critical organs in PRRT. A dosimetry protocol was implemented in an ongoing study to estimate the biological effective dose (BED) on the kidneys after 90Y-DOTATOC therapy.
Aim(s): 111In-octreotide dosimetry with amino acid infusion is feasible and can be used in the prediction of post-PRRT evolution of the renal function.
Materials and methods: Whole body images were acquired at four time points after an 111In-octreotide injection with 2L amino acid coinfusion, assuming similar kinetics of 111In-octreotide and 90Y-DOTATOC. Regions of interest were drawn, blood and urine were collected, kidney volumes were measured, and all put into OLINDA software, which led to organ BED after four cycles 90Y-DOTATOC.
Conference: 8th Annual ENETS Conference (2011)
Category: Clinical
Presenting Author: Dr. Sofie M.D.A. Van Binnebeek

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