Effect of Dacarbazine Chemotherapy in Well-Differentiated Neuroendocrine Tumors

#754

Introduction: Streptozocin-based chemotherapies are widely used in pancreatic NEN. Dacarbazine (DTIC) (650mg/m2 every four weeks) can easily be applied in an outpatient setting, but data on efficacy are limited.

Aim(s): Analysis of the efficacy of chemotherapy with DTIC in patients with progressive metastasized neuroendocrine tumors (NEN) and the predictive value of MGMT status.

Materials and methods: Seventy-nine pts (41 males, 38 females) were enrolled in this open trial. Primary tumor localization was midgut in 12, hindgut in two, bronchus in six, stomach in two, thymus in one, pancreas in 52 and unknown in four patients, respectively. Eight courses of DTIC were administered in median (range 1 - 46). For all but four pts DTIC was at least second line therapy. The MGMT expression was measured in 21 pts by immunohistochemistry using paraffin-embedded tissues.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Mueller D, Krug S, Majumder M, Gress T, Rinke A,

Keywords: NEN, DTIC, MGMT,

Effect of Dacarbazine Chemotherapy in Well-Differentiated Neuroendocrine Tumors

#534

Introduction: Despite encouraging results of streptozocin combinations in patients with metastatic endocrine pancreatic tumors, this treatment modality consists of a five-day cycle and can cause renal insufficiency. Dacarbazine (DTIC) (650mg/m2 every four weeks) can easily be applied in an outpatient setting, but data on efficacy are limited.

Aim(s): Analysis of the efficacy of chemotherapy with DTIC in patients with histologically proven progressive metastasized neuroendocrine tumors (NET).

Materials and methods: Forty-four pts (24 males, 20 females) were enrolled in this open trial. Primary tumor localization was midgut in three, hindgut in one, bronchus in four, stomach in one, pancreas in 32 and unknown in three patients, respectively. The median age was 58 years (range 28-75). Seven courses of DTIC were administered in median (range 1-43).

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Müller D, Rinke A, Gress T,

Keywords: neuroendocrine tumor, chemotherapy, dacarbazine,