Introduction: Kidneys are the critical organs in peptide receptor radionuclide therapy (PRRNT) of neuroendocrine neoplasms (NENs).
Aim(s): To examine if there was a correlation between mean absorbed dose to kidneys and renal toxicity after PRRNT.
Materials and methods: This was a retrospective study of 86 NEN patients who underwent at least three cycles of PRRNT using Lu-177 labeled DOTATATE / DOTATOC and were followed up for 12 months after the third cycle concerning deterioration in renal function. Dosimetric calculations were performed according to MIRD scheme. Changes in renal function were monitored by serial measurements of tubular extraction rate (TER) using Tc-99m MAG3 and of glomerular filtration rate (GFR) using Tc-99m DTPA.
Conference: 10th Annual ENETS Conference 2013 (2013)
Category: PRRT-Ablative therapies-Endoscopic treatment
Presenting Author: Dr. Harshad Kulkarni
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