Effect of Treatment with Prolonged-Release Somatostatin Analogues on the Concentration of Serum Fibrosis Markers in Patients with Carcinoid Syndrome.

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Introduction: A fibrosis is a major local and/or distant complication of neuroendocrine tumours (NETs) of the small intestine secreting serotonin. Tumour cells produce connective tissue growth factor CTGF and transforming growth factor TGFα and TGFβ which locally stimulate fibrosis and cause distant fibrosis.

Aim(s): Assessment the level of serum fibrosis markers CTGF and TGFβ in patients with carcinoid syndrome before and after 12 months treatment with prolonged-release somatostatin analogues

Materials and methods: 30 patients with carcinoid syndrome, the serum level of serotonin, CTGF and TGFβ and 24-hour urinary 5-hydroxy indoles acetic acid (5-HIAA) before and after 12 months of treatment with somatostatin analogues were the subject of researches.The control group consisted of 20 healthy individuals

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Foltyn W, Zemczak A, Rosiek V, Kilian-Kita A, Kos-Kudła B,

Keywords: fibrosis,CTGF,TGFβ,carcinoid syndrome,