Efficacy of Everolimus and Tolerability with Long-Term Use

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Introduction: Predictors of response to Everolimus in neuroendocrine tumors and long-term safety data are lacking.

Aim(s): To assess disease control rate (DCR) and progression-free survival (PFS) with respect to the number of prior treatment lines and evaluation of frequency and timeframe of pneumonitis.

Materials and methods: We analyzed 60 patients (pts) treated with Everolimus +/- Octreotide LAR 30 mg. Median follow-up was 15 months. Location of primary tumor (PT) was in the pancreas or ileum in 24 cases each (41%), respectively, followed by lung (9%, n=5) and others (CUP, rectum, stomach).

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Heetfeld M, Tischer E, Denecke T, Perez Fernandez C, Wiedenmann B,

Keywords: everolimus, prior therapies, pneumonitis ,

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