ENETS studies

Project title: “Studying poor responders to Temozolomide (TMZ) in Pancreatic Neuroendocrine Tumours (PanNET); Unravelling mechanisms of primary resistance”.

Project aims:

• Identifying molecular signatures able to predict response to Temozolomide in PanNET patients
• DNA methylation, transcriptome and Copy Number Variation analysis as well as DNA sequencing will be performed on PanNET tissue from patients treated with Temozolomide
• Bioninformatic analysis will be conducted to identify molecular signature and specific pathways correlating with Temozolomide response
• The markers identified will be validated on additional samples.

Principal investigator: Institute of Pathology, University of Bern, Ilaria Marinoni

This project is supported through an ENETS synergy grant.