Epirubicin Loaded Polyphosphazene; A New Agent Against Small Intestinal Neuroendocrine Tumors and Medullary Thyroid Carcinomas

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Introduction: Small intestinal neuroendocrine tumors (SI-NETs) represent a group of rare neoplasms, derived mainly from enterochromaffine cells. Medullary thyroid carcinoma (MTC) is a calcitonin-producing neuroendocrine tumor arising from the parafollicular C-cells. SI-NETs as well as MTCs are known for their poor response to standard therapy. Therefore, there is a substantial need to establish new therapeutic options in the clinical treatment of these tumors.

Aim(s): Earlier studies have demonstrated antiproliferative and tumoristatic effects of epirubicin. In this study we investigated the effects of a novel water soluble drug carrier agent, polyphosphazene on small intestinal neuroendocrine tumors and medullary thyroid carcinomas.

Materials and methods: SI-NET and the MTC cell lines were incubated with unloaded and epirubicin loaded polyphosphazenes, and cells were analysed using cell counting and WST-1 cytotoxicity assay. Fibroblasts served as contol cells. In addition, MTC xenografts were treated with unloaded, epirubicin loaded polyphosphazene, and epirubicin intra venous.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Schwach G, Pfragner R, Hoeger H, Schoefberger W, Wilfert S,

Keywords: epirubicin, polyphosphazene, neuroendocrine tumor,