Evaluate the Accuracy of Pathological Diagnosis on Biopsy Specimens from Gastrointestinal Neuroendocrine Tumors

#1429

Introduction: Gastrointestinal neuroendocrine neoplasms (GI-NENs) is a highly heterogeneous tumor. The accuracy of pathological diagnosis on the biopsy is crucial for GI-NENs but rarely investigated

Aim(s): To investigate the accuracy of pathological diagnosis on biopsy samples of GI-NENs

Materials and methods: Totally 54 paired biopsy and surgical GI-NENs cases from our hospital were retrospectively analyzed, 21 cases of low differentiated adenocarcinoma of the same period were randomly selected as control. We have used Immunohistochemistry (IHC) of Synaptophysin (Syn), Chromogranin-A (CgA), CD56(NCAM), CK, Ki-67 and special staining (AB-PAS, Mucus card red) to confirm the neuroendocrine component and the grade of the tumor. The consistence of the diagnosis between the biopsy and surgical samples was further evaluated.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Sun L

Authors: Sun L, Li S, Li J, Lu M, Luo J,

Keywords: Gastrointestinal neuroendocrine neoplasm, morphology, Immunohistochemistry,