Evaluation of Mucin and Neuroendocrine Expression in Diffuse Gastric Cancer with Signet Ring Cell Morphology

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Introduction: A proportion of diffuse gastric carcinoma, according to the Lauren classification system, has signet ring cell morphology. Signet ring cells are characterized by a peripherally placed nucleus and a central amorphous substance, which is reported to be mucin based on Periodic Acid Schiff positivity (PAS). PAS is not a specific staining method for mucin. Neuroendocrine expression has previously been reported in tumor cells in diffuse type gastric cancer.

Aim(s): To assess the exocrine and neuroendocrine properties of diffuse gastric cancer with signet ring cell morphology.

Materials and methods: Relevant gastrointestinal mucins and neuroendocrine markers were assessed by immunohistochemistry and in situ hybridization (ISH) by the use of a new and improved ISH method.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Sørdal �

Authors: Sørdal �, Qvigstad G, Nordrum I, Waldum H,

Keywords: gastric signet ring cell carcinoma, mucin, neuroendocrine markers, PAS,