Introduction: Ewing sarcoma (ES) primary to the ileum (IES) has rarely been documented, and shows close similarities in histology and clinical presentation with PDEC.EWSR1-FEV translocation is exceedingly rare in ES, as FEV expression is restricted to prostate, brain, and serotonin neuroendocrine cells (NE) and related tumors.
Aim(s): Little is known about the pathogenesis and clinical implications of IES, which may be critical to identifying novel molecular markers.
Materials and methods: Among 445 ES cases, spanning a period of 20 years, seven (1.6%) were IES. Seven IES were investigated through immunohistochemistry, RT-PCR (EWSR1-FLI1,EWSR1-ERG and EWSR1-FEV transcripts), FISH analysis (EWSR1 break-apart and specific EWSR1-FEV translocation) and spectral karyotyping (SKY). Ten ileum neuroendocrine tumors (INET) made up the control group for EWSR1-FEV translocation.
Conference: 11th Annual ENETS Conference 2014 (2014)
Category: Pathology, grading, staging
Presenting Author: MD, PhD Massimo Milione
, Gasparini P
, Coppa J
, Pusceddu S
, Pellegrinelli A
, Collini P
, Concas L
, Buzzoni R
, De Braud F
, Pilotti S
, Mazzaferro V
, Pelosi G
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