Exclusive Hotspot Mutation of YY1 Gene in Insulinomas and Extensive Mutation of DAXX in PNETs Abstract #1160

Introduction: Somatic mutation of YY1 was shown in sporadic insulinoma, the main type of functional PNET. DAXX mutation occurred mainly in NF-PNET. However, YY1 and DAXX mutations in non-insulinomas and insulinomas, respectively, have not been well elucidated.
Aim(s): To assess somatic mutations of YY1 and DAXX in PNET.
Materials and methods: DNA from 132 tumor tissues (37 NF, 77 insulinomas, 11 gastrinomas, 5 glucagonomas, 2 VIPomas) were extracted. YY1 gene was sequenced in all 132 PNET, DAXX gene was sequenced in 81 (45 insulinomas and 36 non-insulinomas). IHC staining of YY1 was performed in all PNET. Data were correlated with clinicopathologic features
Conference: 12th Annual ENETS Conference (2015)
Category: Basic Science - Genetics, epigenetics, miRNAs
Presenting Author: Dr Yuan-Jia Chen
Keywords: YY1, daxx, mutation, PNET

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