Exclusive Hotspot Mutation of YY1 Gene in Insulinomas and Extensive Mutation of DAXX in PNETs
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Introduction: Somatic mutation of YY1 was shown in sporadic insulinoma, the main type of functional PNET. DAXX mutation occurred mainly in NF-PNET. However, YY1 and DAXX mutations in non-insulinomas and insulinomas, respectively, have not been well elucidated.
Aim(s): To assess somatic mutations of YY1 and DAXX in PNET.
Materials and methods: DNA from 132 tumor tissues (37 NF, 77 insulinomas, 11 gastrinomas, 5 glucagonomas, 2 VIPomas) were extracted. YY1 gene was sequenced in all 132 PNET, DAXX gene was sequenced in 81 (45 insulinomas and 36 non-insulinomas). IHC staining of YY1 was performed in all PNET. Data were correlated with clinicopathologic features
Conference: 12th Annual ENETSConcerence (2015)
Presenting Author: Song Y
Authors: Song Y, Qiao X, Bai C, Lu C, Chen J,
Keywords: YY1,daxx,mutation,PNET,
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