Expression and Clinical Significance of Somatostatin Receptor Subtype 2A in Small Cell Lung Carcinoma Abstract #1653

Introduction: Somatostatin receptors (SSTRs) play a key role in the regulation of cell proliferation and have been identified in a proportion of aggressive poorly differentiated neuroendocrine neoplasms, including small cell lung carcinomas (SCLCs).
Aim(s): This study aimed to assess the prognostic value of SSTR subtype 2A (SSTR2A) expression in SCLC patients with limited- and extensive-disease.
Materials and methods: SSTR2A expression was evaluated by immunohistochemistry (IHC) with the monoclonal antibody UMB-1 in 52 biopsy samples from primary tumors (n=45) or metastases (n=7) of SCLC patients. SSTR2A expression status in tumor was correlated to progression-free (PFS) and overall survival (OS).
Conference: 14th Annual ENETS conference 2017 (2017)
Category: Non digestive NETs (bronchial, MTC pheochromocytoma) Pathology, grading, staging
Presenting Author: Vera Delektorskaya

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