Expression and Clinical Significance of Somatostatin Receptor Subtype 2A in Small Cell Lung Carcinoma

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Introduction: Somatostatin receptors (SSTRs) play a key role in the regulation of cell proliferation and have been identified in a proportion of aggressive poorly differentiated neuroendocrine neoplasms, including small cell lung carcinomas (SCLCs).

Aim(s): This study aimed to assess the prognostic value of SSTR subtype 2A (SSTR2A) expression in SCLC patients with limited- and extensive-disease.

Materials and methods: SSTR2A expression was evaluated by immunohistochemistry (IHC) with the monoclonal antibody UMB-1 in 52 biopsy samples from primary tumors (n=45) or metastases (n=7) of SCLC patients. SSTR2A expression status in tumor was correlated to progression-free (PFS) and overall survival (OS).

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Delektorskaya V, Kusminov A, Ivanov A, Gorbunova V,

Keywords: small cell carcinoma, lung, immunohistochemistry,