Expression and Prognostic Role of CXCR4/CXCL12/CXCR7 and mTOR Pathways in Neuroendocrine Tumors (NETs)

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Introduction: The chemokine receptor CXCR4 interacts with the ligand CXCL12 to exert proliferative and chemotactic effects. CXCR4 activates mTOR through phosphorylation of its two effectors downstream:4EBP1and S6K

Aim(s): To evaluate expression and prognostic role of CXCR4-CXCL12-CXCR7, as well as mTOR pathways in a consecutive series of patients with endocrine tumors (NETs)

Materials and methods: 53 human NETs were included: 16 P-NET,19 GI-NET, and 18 MTC were analyzed for expression of CXCR4, CXCL12 and CXCR7 by qRT-PCR. Moreover, CXCR4, CXCL12 and CXCR7 and mTOR pathway was evaluated by immunohistochemistry (IHC) in the patient cohort

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Circelli L, Sciammarella C, Faggiano A, Tafuto S, Pezzullo L,

Keywords: Chemokine, mTOR, NETs, clinical outcome,