Expression of EGFR and IGF Pathway Genes in Insulinomas Abstract #319

Introduction: Anti-epidermal growth factor receptor (EGFR) therapy has been suggested in patients with inoperable/progressive endocrine pancreatic tumors (EPTs). However, various % EGFR-expressing EPTs are reported.
Aim(s): To examine the expression of EGFR and insulin-like growth factor (IGF) pathway genes in insulin-expressing EPTs (insulinomas).
Materials and methods: We determined EGFR, pERK and pAKT immunostaining by routine immunohistochemistry on paraffin-embedded tissue sections (181 EPTs, including 65 insulinomas). Furthermore, EGFR, ERK and AKT mRNA expression, as well as mRNA expression of IGF pathway genes (IGF, IGFR, InsR, IGFBP) were analyzed in 26 insulinomas and normal tissue by quantitative RT-PCR.
Conference: 8th Annual ENETS Conference (2011)
Category: Basic
Presenting Author: Dr Ernst-Jan M Speel

To read results and conclusion, please login ...

Further abstracts you may be interested in

#1936 The Expression of IGF Signaling Pathway Genes Is Frequently Elevated in Pancreatic Neuroendocrine Tumors, but Is Downregulated in Metastases
Introduction: Studies have implicated EGFR, IGF and mTOR signaling pathways in the regulation of pNET growth. Interpretation of these studies is complex due to tumor subtype heterogeneity and differences in molecular analysis.
Conference: 14th Annual ENETS conference 2017 (2017)
Category: Basic Science - Signaling pathways, receptors, biomarkers
Presenting Author: Prof. Dr. Ernst-Jan Speel
#2682 PAK4-NAMPT Dual Inhibition as a Novel Strategy for Therapy Resistant Pancreatic Neuroendocrine Tumors
Introduction: Pancreatic neuroendocrine tumors (PNET) remain an unmet clinical need. In this study, we show that targeting both nicotinamide phosphoribosyltransferase (NAMPT) and p21-activated kinase 4 (PAK4) could become a synthetic lethal strategy for PNET.
Conference: 17th Annual ENETS Conference 2020 (2020)
Category: Basic Science - Signaling pathways, receptors, biomarkers
Presenting Author: Ph.D. Candidate Gabriel Mpilla
Authors: Mpilla G, Aboukameel A, Muqbil I, Kim S, ...
#2685 Apatinib Inhibits Tumor Growth and Angiogenesis in PNET Models
Introduction: Angiogenesis has a pivotal role in the growth and metastasis of pancreatic neuroendocrine tumors (PNETs). Apatinib inhibits angiogenesis as a highly selective KDR inhibitor and has been used to treat advanced gastric cancer and malignancies in clinical settings. However, the efficacy of apatinib in PNETs remains unclear.
Conference: 17th Annual ENETS Conference 2020 (2020)
Category: Basic Science - In vitro models, tumor growth, CTCs
Presenting Author: Shan Wu
Authors: Wu S, Zhou J, Guo J, Hua Z, ...
#2693 The Distinctive Character of Micro-Vasculature and Immune Cell Infiltration in Cystic Pancreatic Neuroendocrine Tumors
Introduction: Hypervascularity is main character of pancreatic neuroendocrine tumors (PanNETs), cystic PanNET (CPanNET) are unique type of PanNETs for which the microenvironment remains unknown.
Conference: 17th Annual ENETS Conference 2020 (2020)
Category: Biomarkers
Presenting Author: Heli Gao
Authors: Gao H, ...
#2694 The Incidence of Gastrointestinal Neuroendocrine Tumors in the Russian Population
Introduction: Over the past four decades, the incidence of neuroendocrine tumors (NETs) has increased. The limited choice of treatments, broad clinical variability of the syndrome explains the increased interest in NETs.
Conference: 17th Annual ENETS Conference 2020 (2020)
Category: Epidemiology/Natural history/Prognosis - Registries, nationwide and regional surveys
Presenting Author: Alina Isiangulova