Expression of m-TOR Pathway Components in Gastric Neuroendocrine Neoplasms: A Pilot Study

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Introduction: The mammalian target of rapamycin (mTOR) signaling pathway plays a key role in the regulation of cell proliferation, protein synthesis and neuroendocrine tumor growth.

Aim(s): This study aimed to assess the activation of the mTOR pathway in the different types of gastric neuroendocrine neoplasms (gNENs) and to correlate expression with clinicopathological variables and prognosis.

Materials and methods: Immunohistochemistry (IHC) was performed to assess the expression of phosphorylated mTOR (p-mTOR) and its downstream target, the eukaryotic initiation factor 4E-binding protein 1 (4EBP1) in 34 surgically resected gNENs.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Delektorskaya V, Peregorodiev I, Bokhian V, Stilidi I,

Keywords: neuroendocrine, neoplasm, gastric, immunohistochemistry ,