Expression of PTEN and mTOR in Pancreatic Neuroendocrine Tumors and Their Clinical Significance Abstract #592

Introduction: mTOR is currently under investigation as a potential target for anticancer therapy. Loss of PTEN, the negative regulators of the PI3K-Akt-mTOR pathway, have been associated with cancer.
Aim(s): To clarify the expression patterns of p-mTOR, mTOR and PTEN in normal islets and primary pancreatic neuroendocrine tumors (pNETs) and their significance in predicting clinical behaviors and outcomes.
Materials and methods: The expressions were assessed in 20 normal pancreatic islets and in 90 resectable pNETs.
Conference: 10th Annual ENETS Conference (2013)
Category: Epidemiology/Natural history/Prognosis - Prognosis
Presenting Author: Xu Han
Authors: Han X, Ji Y, Zhao J, Xu X, Lou W

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