Expression of Somatostatin Receptors in Gastroenteropancreatic Neuroendocrine Neoplasm and Multicenter Retrospective Clinical Study of Octreotide LAR in the Treatment of Advanced GEP-NET

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Introduction: Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs) are known to overexpress somatostatin receptors(SSTRs),which forms the basis for octreotide long-acting repeatable(LAR) treatment in NEN.

Aim(s): To detect the expression of SSTR subtypes 2 and 5 in GEP-NEN and investigate the efficacy and safety of octreotide LAR in the treatment of well-differentiated advanced GEP-NET in China.

Materials and methods: We conducted a multicenter retrospective study including four centers from across China.SSTR2 and SSTR5 expression were examined in 165 specimens by immunohistochemistry.The clinical data of 54 patients who received octreotide LAR were analyzed.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Jie C

Authors: Yuhong W, Wei W, Kaizhou J, Cheng F, Zhiwei Z,

Keywords: gastroenteropancreatic neuroendocrine neoplasm, somatostatin receptor, octreotide, treatment,

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