Expression of the Truncated Somatostatin Receptor Variant Sstr5TMD4 in Medullary Thyroid Carcinoma Abstract #986

Introduction: Medullary thyroid carcinoma (MTC) is a rare tumor originating from thyroid parafollicular C cell. The only available treatment is surgical resection, which is not always feasible. Somatostatin and its receptors are expressed both in normal human thyroid C cells and in MTC, but their role has not been fully elucidated. The discovery of a truncated isoform of Sstr5, Sstr5TMD4, associated with increased invasiveness and aggressiveness in breast cancer, has opened new insight in the role of Sstr in cancers.
Aim(s): To evaluate Sstr5TMD4 expression in a series of human MTC at different stages, and to explore the role of Sstr5TMD4 in TT human MTC cell line.
Materials and methods: Sstr5TMD4 expression correlates with disease stage and that it is higher in MTC metastases v. primary site and in sporadic v. hereditary cases.
Conference: 11th Annual ENETS Conference (2014)
Category: Basic Science - mTOR and other pathways, signalling, receptors
Presenting Author: Dr Daniela Molè
Keywords: MTC, SSTR5TMD4

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