Expression of UCH-L1 in Pancreatic Endocrine Tumors and Its Clinical Significance

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Introduction: Pancreatic endocrine tumors (PETs) are rare tumors with distinct clinical syndromes. There is a lack of reliable biomarker to distinguish benign and malignant form of PETs as well as to predict its prognosis. Our previous proteomic study on insulinoma found that overexpression of UCH-L1 in tumors. The diagnostic or prognostic value of this protein has not been well addressed in PETs.

Aim(s): To identify the expression of UCH-L1 in PETs and its clinical implications, to reveal the epigenetic mechanism underlying the expression of UCH-L1 in PETs.

Materials and methods: 226 PETs and 79 paired pancreatic tissues were included in our study. Of 221 patients, 167 were followed up. Immunohistochemistry staining (IHC) were used to test the protein expression. Methylation status of the gene promoter was detected by MSP and bisulfited sequencing. Chi-square, Kaplan-Meier analysis and logistic regression were used for statistical analysis.

Conference:

Presenting Author:

Authors: Qiao X, Wan Y, Tang L, Lu C, Xiao Y,

Keywords: pancreatic endocrine tumors, UCH-L1, biomarker,