External Validation of Prognostic Classification Score for Predicting Overall Survival (OS) of Patients (pts) with Advanced Well Differentiated Neuroendocrine Tumour (WDNET). Neuroendocrine European Prognostic Score (NEP Score Working Group)

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Introduction: Absence of relevant prognostic score (PS) in NET

Aim(s): To meet a current need for WDNET pts counseling or stratification in clinical trials, building a PS for OS

Materials and methods: Data of 515 pts treated at INT (Milan ENET Center of Excellence) from 1986 to 2012, were used (Training Set, TS). Prognostic covariates were selected in a multivariable Cox model; the final model included patients’age at metastasis, gender, site of primary tumor, metastasis site, time to metastasis, grading, functional status, and primary tumor resection; a 3-classes score was derived by classifying pts based to predicted 10-year OS:1) ≥70%; 2) ≥30% and <70%; 3) <30%. External validation was performed applying the score to 2 independent sets: population-based data of the RARECARE-net project (validation set 1, VS1, 457 pts) and pancreatic WDNETs cohort (VS2, 415 pts) of Italian multicenter group. The score was evaluated by examining calibration and discrimination (Harrell C index).

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Pusceddu S

Authors: Pusceddu S, Barretta F, Botta L, Trama A, Milione M,

Keywords: neuroendocrine, prognostic score,