ENETS Abstract Search

Filamin-A Is Required for Somatostatin Receptor 2 (SST2) Stabilization, Signaling and Angiogenesis Regulation in Gastroenteropancreatic Neuroendocrine Tumors

#1075

Introduction: Somatostatin receptor type 2 (SST2) is the main pharmacological target for GEP-NETs. A subset of patients is resistant to somatostatin analogs (SSa), although the molecular mechanisms responsible for resistance are poorly understood. Several studies identified cytoskeleton protein as determinant in receptor anchoring and signaling

Aim(s): Since SST2 was demonstrated to associate with ubiquitous cytoskeleton protein Filamin A (FLNA), the aim was to investigate the role of FLNA in SST2 expression, signaling and angiogenesis in GEP-NETs and QGP1 cell line.

Materials and methods: We analyzed FLNA and SST2 expression by IHC and western blot and the role of FLNA by gene silencing

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Vitali E, Cambiaghi V, Loiarro F, Zerbi A, Colombo P,

Keywords: FLNA, SST2, GEP-NET,

To read the full abstract, please log into your ENETS Member account.