Functional Imaging Tests versus Computed Tomography Scan: Detection of New Metastases and Clinical Usefulness in Digestive Neuroendocrine Neoplasms Follow-Up

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Introduction: Digestive Neuroendocrine Neoplasms (DNENs) express in 80% of cases somatostatin receptors (SSTRs) detected by functional imaging tests (FITs). FITs are needed at diagnosis to define therapy but their role in follow-up (FU) is unclear

Aim(s): To compare accuracy in detecting new lesions (primary outcome) and clinical usefulness (secondary outcome) of FITs and Computed Tomography scan (CT) in stage IV DNENs FU

Materials and methods: Retrospective analysis of stage IV DNENs expressing SSTRs with at least 24 month-FU. From 1995 to 2008 FIT was Octreoscan (OCT), from 2008 to 2013 68Ga-DOTANOC PET (GaPET). CT was repeated every 6-12 months, FIT yearly. FU time was divided in 12 month-“units” (in which pts had at least 1 CT and 1 FIT), analyzed separately and compared to each other. Gold standard was the result of imaging, surgical and pathology findings collected for each pt in FU. Clinical usefulness was defined as appropriate changes in management (new imaging, therapy, surgery, biopsy) due to CT or FITs

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Merola E

Authors: Merola E, Panzuto F, Capurso G, Kump P, Lipp R,

Keywords: Metastatic, DNENs, follow-up, FIT, CT,