Gastrinoma and Neurofibromatosis Type 2: Is There an Association?

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Introduction: Gastroenteropancreatic neuroendocrine tumors have been seldom described in association with neurofibromatosis type-1, whereas an association with neurofibromatosis type-2 (NF2) has never been reported.

Aim(s): To present a case of a woman with NF2 and concomitant pancreatic gastrinoma.

Materials and methods: We refer to a 69-year-old-woman presenting with weight loss and a history of heartburn and diarrhea. The patient is responsive to proton-pump-inhibitors. She was previously diagnosed as having an NF2-syndrome, according to internationally accepted clinical criteria, as she had encephalic meningiomas, a tongue schwannoma and bilateral acoustic neurinomas.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Rossi R

Authors: Massironi S, Zilli A, Cavalcoli F, Rossi R, Conte D,

Keywords: Gastrinoma, neurofibromatosis type-2, MEN-1,