Gastro-Entero-Pancreatic Mixed Adenoneuroendocrine Tumors. Report of Four Cases.

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Introduction: Mixed adenoneuroendocrine carcinomas (MANECs) is an uncommon entity with ill-defined clinicopathologic characteristics.

Aim(s): To present four cases of MANECs located on different sites of gastrointestinal tract. In addition, we aimed to investigate immunohistochemically the expression of epithelial-neuroendocrine markers, the proliferative index Ki67/MIB1 and MMR proteins.

Materials and methods: Four cases of tumors located on the gastro-esophageal junction, sigmoid, appendix and pancreas were included. Immunohistochemical study for epithelial, neuroendocrine markers, Ki67/MIB1 proliferative index, was performed. The microsattelite instabillity pathway (MSI) was immunohistochemically investigated, as well.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: we do not want to present it orally

Authors: Koletsa T, Iliadis A, Tzioufa V, Karayannopoulou G,

Keywords: Mixed adenoneuroendocrine tumors, immunohistochemistry, MMR proteins, MSI,