GastroEnteroPancreatic and Thoracic Neuroendocrine Tumors and the Ectopic Adrenocorticotropin Syndrome
#1142
Introduction: Ectopic Adrenocorticotropin (ACTH) Syndrome (EAS) is associated with a variety of malignancies, predominantly of neuroendocrine origin. Several series report on the relative contribution of EAS in the spectrum of Cushing’s syndrome. However, information on the incidence/prevalence and prognosis of EAS in the setting of patients diagnosed with Thoracic or GEP-NETs is virtually absent.
Aim(s): Screening of a large consecutive series of thoracic and GEP-NET patients for the presence/occurrence of EAS in a retrospective case-record study in a tertiary academic referral center.
Materials and methods: 918 patients diagnosed with thoracic or GEP-NETs between 1993-2012 were studied. MEN1 & SCLC were excluded. We differentiated between synchronous, metachronous and cyclic occurence of EAS. Synchronous EAS was defined as 6 months before and 6 months after first diagnosis of thoracic or GEP-NET. Overall survival was analyzed using a KM curve.
Conference: 12th Annual ENETSConcerence (2015)
Presenting Author: Kamp K
Authors: Kamp K, Alwani R, De Herder W, Feelders R,
Keywords: GEP-NET, thoracic, ACTH, Cushing,
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