Gene Expression Characterization of Gastroenteropancreatic Neuroendocrine Tumors [GEPNETS: Gastrointestinal and Pancreatic NETs (GINETs and pNETs)] and Their Correlation with Clinical Factors and Tumor Behavior

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Introduction: GEP-NETs are a heterogenous group of tumors with different molecular backgrounds and clinical outcome.

Aim(s): To further characterize GEP-NET gene expression and correlate with clinical characteristics and tumor behavior.

Materials and methods: Forty fresh-frozen tumor samples (20 G1-2 GINETs and 20 G1-2 pNETs) were collected from 12 Spanish centres. Tumoral mRNA expression (copy number) of sst4, PDGF, RET, VEGFR, angiopoietin (Ang)1, Ang2, Tie2, β-catenin, E-cadherin, HIF1A, HIF1B, THBS1, adrenomedullin (AM), CD34, PTEN, Notch and mTOR was analyzed by quantitative PCR.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Martínez-Fuentes A

Authors: Díaz Pérez J, García-Carbonero R, Villabona C, Capdevila J, Jiménez-Fonseca P,

Keywords: sst4, RET, angiogenesis, GEP-NET,