Gene Silencing by Promoter Hypermethylation in SI-NETs Abstract #676

Introduction: Aberrant DNA methylation is an important feature of human cancer affecting corresponding gene expressions and clinical features in different tumors, including SI-NETs.
Aim(s): To determine methylation density and its effect on gene expression levels in SI-NET tumors and cell lines.
Materials and methods: Forty-four SI-NET tumors and nine adjacent normal samples were included. The cell lines CNDT2 and HC45 were evaluated before and after treatment with 5-Aza cytidine. Promoter methylation density was quantified by Pyrosequencing.
Conference: 10th Annual ENETS Conference (2013)
Category: Basic Science - Genetics, epigenetics, miRNAs
Presenting Author: Omid Fotouhi
Keywords: SI-NET

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