Gene Silencing by Promoter Hypermethylation in SI-NETs

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Introduction: Aberrant DNA methylation is an important feature of human cancer affecting corresponding gene expressions and clinical features in different tumors, including SI-NETs.

Aim(s): To determine methylation density and its effect on gene expression levels in SI-NET tumors and cell lines.

Materials and methods: Forty-four SI-NET tumors and nine adjacent normal samples were included. The cell lines CNDT2 and HC45 were evaluated before and after treatment with 5-Aza cytidine. Promoter methylation density was quantified by Pyrosequencing.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Fotouhi O, Hashemi J, Kjellman M, Höög A, Zedenius J,

Keywords: SI-NET,