Genes Involved in Angiogenesis and mTOR Are Frequently Found Mutated in Asian Patients with Pancreatic Neuroendocrine Tumors.

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Introduction: There are limited data and inconsistent findings of genetic alteration in pancreatic neuroendocrine tumors (pNET).

Aim(s): We sequenced genes known to be associated with pNET and analyzed their impact on clinical outcomes in a Taiwanese cohort.

Materials and methods: Tissue samples from 40 Taiwanese patients with sporadic pNETs were sequenced using a customized sequencing panel that analyzed 43 genes known to be potentially associated with pNET. Genetic mutations and clinical outcomes were analyzed for potential association.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Wen-Chi C, Yi-Chen Y, Yi-Ming S, Yee C, Po-Han L,

Keywords: pancreatic NETs, gene mutation, mTOR,