Introduction: Glucagon cell adenomatosis (GCA) was recently recognized by us as a multifocal neoplastic disease of the endocrine pancreas unrelated to MEN-1. Multiple micro- and a few macrotumors are found on the background of a hyperplasia of glucagon cells. The disease may cause unspecific abdominal symptoms and only rarely a glucagonoma syndrome. Recently a mutation in the glucagon receptor (GCGR) gene was described in one GCA
Aim(s): To investigate GCGR gene changes in five patients with GCA.
Materials and methods: Paraffin-embedded and formalin-fixed pancreatic tissues from five patients with GCA were macro- or microdissected. The extracted DNA was sequenced and the GCGR gene analysed for mutations.
Conference: 9th Annual ENETS Conference (2012)
Presenting Author: Dr. Tobias Henopp
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