Genetic Alterations in Glucagon Cell Adenomatosis

#564

Introduction: Glucagon cell adenomatosis (GCA) was recently recognized by us as a multifocal neoplastic disease of the endocrine pancreas unrelated to MEN-1. Multiple micro- and a few macrotumors are found on the background of a hyperplasia of glucagon cells. The disease may cause unspecific abdominal symptoms and only rarely a glucagonoma syndrome. Recently a mutation in the glucagon receptor (GCGR) gene was described in one GCA patient.

Aim(s): To investigate GCGR gene changes in five patients with GCA.

Materials and methods: Paraffin-embedded and formalin-fixed pancreatic tissues from five patients with GCA were macro- or microdissected. The extracted DNA was sequenced and the GCGR gene analysed for mutations.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Henopp T, Anlauf M, Biskup S, Klöppel G, Sipos B,

Keywords: glucagon,

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