Genome-Wide Analysis of Long Non-Coding RNAs in Pancreatic Neuroendocrine Tumors by Microarray

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Introduction: LncRNAs have been shown to play important roles in cancer biology,but expression profile of lncRNAs in pancreatic neuroendocrine tumors(pNETs) is not well understood.

Aim(s): This study was to uncover the role of lncRNA in the process of pNETs development using microarray to obtain the expression profiles of lncRNAs in pNETs and their adjacent normal tissues.

Materials and methods: 18 pairs of pNET G1/G2 tissues were used in this study.The detection of lncRNA and transcripts was conducted using microarray analysis.Gene ontology and pathway analyses were performed to understand the biochemical function of lncRNA.qRT-PCR was performed to validate the consistency of the lncRNAs with microarray data.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Ji M,

Keywords: LncRNA,pancreatic neuroendocrine tumors,microarray,gene ontology analysis, pathway analysis,

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