Genome-Wide MicroRNA Expression in Small Intestine Neuroendocrine Tumors (“Midgut carcinoids”): Upregulation of miRNA-182, miRNA-183 and Downregulation of miRNA-215 Abstract #200

Introduction: MicroRNAs (miRs) may regulate cell proliferation, differentiation, apoptosis and function as tumor suppressors or oncogenes. MiR expression is not characterized in neuroendocrine midgut carcinoids.
Aim(s): Investigate miR expression of normal dissected enterochromaffin cells and tumor material to find potential involvement in tumor progression.
Materials and methods: MiR expression in patient material (five primary tumors; five mesentery and five liver metastases) and in laser-microdissected normal enterochromaffin cells and three normal ilea mucosa specimens was analyzed using miRNA Affymetrix microarray. Results were validated both with Q-RT-PCR and Northern Blot.
Conference: 8th Annual ENETS Conference (2011)
Category: Basic
Presenting Author: PhD student Su-Chen Li

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