Ghrelin O-Acyltransferase (GOAT) Enzyme and Ghrelin Receptor GHSR1a as Putative Prognosis Markers and Therapeutic Targets in Gastroenteropancreatic Neuroendocrine Tumors

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Introduction: Specific components of ghrelin-system are associated with tumor development/ progression. We have previously described the presence of this system in neuroendocrine tumors (NETs) but clinical-molecular correlations have not been elucidated yet.

Aim(s): Therefore, this has been the aim of the present study.

Materials and methods: Expression of ghrelin system components in gastroenteropancreatic (GEP)-NETs using qPCR was compared with that of non-tumor adjacent (NTA; n=58) and normal tissues (NT; n=14) and correlated with clinical and histological characteristics. Key results were confirmed by immunohistochemistry. Cell viability in primary cultures and NET cell lines was determined in response to acylated (Ac)-ghrelin and GOAT inhibitor. Migration capacity was also evaluated.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Herrera-Martinez A

Authors: Herrera-Martínez A, Gahete M, Sánchez-Sánchez R, Ortega Salas R, Serrano R,

Keywords: GEP-NET, ghrelin system, GOAT, GHSR1a, prognosis, invasion,