Glycodelin Expression in Pancreatic Neuroendocrine and Solid-Pseudopapillary Tumors as in Important Factor of Favorable Disease Prognosis

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Introduction: Glycodelin (GD) is a multifunctional highly glycosylated protein, expressed in hormone-dependent human tissues and tumors. GD participates in apoptosis regulation and inter-cellular adhesion.

Aim(s): To assess GD production and progesterone receptors' (PR) role in pancreatic malignant tumor cells.

Materials and methods: Forty-three pancreatic tumor specimens examined: 19 neuroendocrine tumors (NET), 14 solid-pseudopapillary (SPT), 10 exocrine carcinomas. We used a semiquantitative method (1-3+) to evaluate cytoplasmic type of GD expression in tumor cells; to evaluate PR expression used PR-index (%) and H score similar to one used in breast cancers.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Gurevich L, Boltovskaya M, Starosvetskaya N, Korsakova N,

Keywords: glycodelin, pancreatic tumors, immunohischemistry, prognosis,