Grading of Metastases in Digestive Neuroendocrine Tumors (NET): Interest for Clinical Management?
#896
Introduction: Therapeutic strategy of NETs is highly dependent on tumor classification according to the WHO system. NETs are frequently classified based on the histological characteristics of the primary tumor associated with the ENETS grading, even for patients with metastases.
Aim(s): To compare the tumor grade between primary NETs and their liver metastases which may exhibit differential proliferative characteristics.
Materials and methods: The cohort harvested seven patients with pancreatic NET and 18 patients with intestinal NET, without genetic syndrome and treated at our institution (13 males, median age 58 years, range 14-79 years). All presented synchronous (19 patients) or metachronous liver metastases. According to the WHO classification, tumor grading was evaluated for primary and metastatic NETs on the Ki-67 and mitotic count and classified as grade G1, G2 or G3.
Conference: 11th Annual ENETSConcerence (2014)
Presenting Author: Dumars C
Authors: Dumars C, Foubert F, Touchefeu Y, Regenet N, Senellart H,
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