Heterogeneity in the Ki-67 Index of Neuroendocrine Tumors Abstract #961

Introduction: Tumor heterogeneity due to tumor evolution is becoming more widely recognised. Neuroendocrine tumors (NET) are routinely graded using the Ki-67 index based on a single tumor location, however, this could lead to undergrading if the Ki-67 index is higher at the metastatic site.
Aim(s): Assess the extent of Ki-67 index heterogeneity in NET.
Materials and methods: Ki-67 index was assessed in 31 NET patients, and determined in all lesions with available tissue. Immunohistochemical staining was done and the Ki-67 index determined according to standard criteria. In 23 patients, tissue was available from the primary and metastatic lesions and in two patients from multiple pancreatic lesions. Sections were taken at five points spaced evenly across metastasis from six explant livers from NET patients.
Conference: 11th Annual ENETS Conference (2014)
Category: Pathology, grading, staging
Presenting Author: Helen Miller

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