High Grade (G3) Neuroendocrine Neoplasms Should Be Further Classified According to Morphological Differentiation

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Introduction: Neuroendocrine neoplasms (NENs) with a Ki-67 >20% (Grade 3) are classified together as Neuroendocrine Carcinomas (NEC), and are usually considered as poorly differentiated. However Grade (G)3 NENs may be heterogeneous, with some demonstrating a well-differentiated cell morphology.

Aim(s): To compare well-differentiated tumors (G3 WD-NETs) to poorly differentiated carcinomas (G3 PD-NECs).

Materials and methods: All G3 NENs referred between 2008 and 2013 were identified from a histopathology database. Clinical data analysed included Ki-67, imaging, response to treatment and overall survival (OS).

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Mandair D, O'Leary J, Luong T, Thirlwell C, Meyer T,

Keywords: Ki-67, g3 NENs,