High Rate of Copy-Number Alterations in Gastrointestinal and Pancreatic Neuroendocrine Tumors with Unidentified Driver Mutations

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Introduction: The driving genetic alteration leading to neuroendocrine tumor (NET) development has been reported for primary tumors of pancreatic origin, but not for metastases. Moreover, even for primary tumor a significant “dark matter” remains to be explored.

Aim(s): To identify driver genetic alteration in gastroenteropancreatic NET (GEP-NET) metastases.

Materials and methods: A hybrid capture sequencing of 500 tumor suppressor genes and oncogenes was performed. Patients’ tumor DNA were sequenced and compared with germline DNA. Copy-number (CN) variant analysis was performed based on the sequencing data.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Tirosh A

Authors: Tirosh A, Killian J, Zhu Y, Neychev V, Meltzer P,

Keywords: GEP-NET, Driver mutation, Copy-number, Metastases,