Hsa-microRNA-202-3p Up-regulated in Type 1 Gastric Neuroendocrine Neoplasms

#1673

Introduction: Type 1 gastric neuroendocrine neoplasm (g-NENs) is a kind of rare malignant tumor. The molecular mechanism of this disease is unknown. MicroRNA (miRNA) plays important roles in the occurrence and development of tumors. At present, research about the role of miRNA in type 1 g-NENs is quite few.

Aim(s): To detect the abnormal expression of miRNA in type 1 g-NENs and predict its target gene.

Materials and methods: The tumor tissues in 3 pts with type 1 g-NENs were taken as the experimental samples, and their gastric mucosal tissues obtained by gastroscopy were taken as the control samples. The expression of miRNAs was examined by Agilent Human miRNA chips. The expression of altered miRNA was validated by RT-PCR in 7 pts. Three target gene prediction software (TargetScan, PITA, microRNAorg) were used to predict the potential target genes of the altered miRNA.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Dou D

Authors: Dou D, Shi Y, Luo J, Tan H,

Keywords: type 1 g-NENs, miR-202-3p, up-regulated,

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