Identification and Validation of the Angiotensin II Receptor Type 1 as a Possible Anti-Cancer Target in Neuroendocrine Tumors

#2294

Introduction: Neuroendocrine tumours (NETs) have been found to overexpress somatostatin receptors (SSTRs), which led to the development of somatostatin analogs utilized for diagnostics and therapeutics. However, around 30% of all NETs do not respond to somatostatin based approaches, leading to an interest to find and characterize alternative cell surface targets.

Aim(s): Characterize AGTR1 as a target in NET.

Materials and methods: RT-qPCR, receptor autoradiography, label-free assay, calcium imaging, radioligand binding assay, proliferation assay, migration assay.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Grötzinger C

Authors: Grötzinger C, Exner S, Wiedenmann B,

Keywords: AGTR1, PRRT, autoradiography, radioligand binding assay,